Project Description
My main focus is the development of numerical tools for the description and analysis of chemical processes. Currently, I’m dedicated to building PharmaPy, an object-oriented tool for the analysis of dynamic pharmaceutical processes. In order to develop PharmaPy, I’ve undergone several research routes such as the analysis of dynamic (and possibly non-smooth) systems, analysis of particulate systems (mainly crystallization), process ontology (model representation and structure), parameter estimation in dynamic systems, and process optimization.
Experience
- Doctoral Intern – Purdue University (Dec 2014 – Jun 2015, Apr 2016 – Nov 2016)
- Lecturer – Heat Transfer (Eafit University, 2012-2019)
- Lecturer – Thermodynamics (I and II) (Universidad de Antioquia, 2018-2019)
Publications
- Casas-Orozco, D., Villa, A.L., Bustamante, F., González, L.-M., 2015. Process development and simulation of pectin extraction from Orange peels. Food Bioprod. Process. 96, 86–98.
- Casas-Orozco, D., Alarcón, E., Villa, A.L., 2015. Kinetic study of the nopol synthesis by the Prins reaction over tin impregnated MCM-41 catalyst with ethyl acetate as solvent. Fuel 149, 130–137.
- Casas-Orozco, D., Alarcón, E., Carrero, C.A., Venegas, J.M., McDermott, W., Klosterman, E., Hermans, I., Villa, A.-L., 2017. Influence of Tin Loading and Pore Size of Sn/MCM-41 Catalysts on the Synthesis of Nopol. Ind. Eng. Chem. Res. 56, 6590–6598.
- Rossi,F., Casas-Orozco, D., Reklaitis, G., Manenti, F., Buzzi-Ferraris, G., 2017. A computational framework for integrating campaign scheduling, dynamic optimization and optimal control in multi-unit batch processes. Comput. Chem. Eng. 107, 184–220.
- Casas-Orozco, D., Villa, A.L., Guerra, O.J., Reklaitis, G. V., 2018. Dynamic parameter estimation and identifiability analysis for heterogeneously-catalyzed reactions: Catalytic synthesis of nopol. Chem. Eng. Res. Des. 134, 226–237.
- Arias, J., Casas-Orozco, D., Cáceres-León, A., Martínez, J., Stashenko, E., Villa, A.L., 2020. Dynamic modeling and experimental validation of essential oils fractionation: Application for the production of phenylpropanoids. Comput. Chem. Eng. 135.
- Casas-Orozco, D., Laky, D., Wang, V., Abdi, M., Feng, X., Wood, E., Laird, C., Reklaitis, G. V., Nagy, Z.K., 2021. PharmaPy: An object-oriented tool for the development of hybrid pharmaceutical flowsheets. Comput. Chem. Eng. 153, 107408.
- Casas-Orozco, D., Laky, D.J., Wang, V., Abdi, M., Feng, X., Wood, E., Reklaitis, G. V., Laird, C.D., Nagy, Z.K., 2021. Application of PharmaPy in the digital design of the manufacturing process of an active pharmaceutical ingredient, in: Turkay, M., Gani, R. (Eds.), 31st European Symposium on Computer Aided Process Engineering. Elsevier, Amsterdam, pp. 333–339.
Conference Presentations
- D. Casas-Orozco, A. L. Villa, L. M. González, S. Ochoa. Modeling the reaction and separation stages in the production of nopol., XXVII Interamerican and Colombian Congress on Chemical Engineering (Colombia), 2013
- F. Rossi,D. Casas-Orozco, G. V. Reklaitis, F. Manenti. Integrated Real-Time Optimization and Control of Multi-unit Batch Processes. AIChE Meeting (USA), 2015
- E. Alarcón, D. Casas-Orozco, C. Carrero, A. L. Villa. Effect of metal loading on the nature and catalytic activity of Sn in Sn/MCM-41 materials for the production of Nopol,. XXV Iberoamerican Congress of Catalysis - CICAT (Uruguay), 2016
- D. Casas-Orozco, A. L. Villa, O. Guerra, G. V. Reklaitis. A Systematic Workflow for the Design of Batch Processes. AIChE Meeting (USA), 2016
- D. Casas-Orozco, D.J. Laky, G.V. Reklaitis, C.D. Laird, S. Lee, M. Abdi, X. Feng, E. Wood, and Z.K. Nagy, 2020. “PharmaPy: A Process Synthesis Framework for Hybrid Pharmaceutical Manufacturing Systems”, 2020 AIChE Meeting (virtual), San Francisco, CA, November 16-20, 2020
- D. Casas-Orozco, D.J. Laky, V. Wang, M. Abdi, X. Feng, E. Wood, G.V. Reklaitis, C.D. Laird, and Z.K. Nagy, 2021. “Application of PharmaPy in the Digital Design of the Manufacturing Process of an Active Pharmaceutical Ingredient.” The 31st European Symposium on Computer Aided Process Engineering (ESCAPE-31, virtual), Istanbul, Turkey, June 6-9, 2021.
- F. Destro, I. Hur, D. Casas-Orozco, S. Lee, M. Abdi, X. Feng, E. Wood, M. Barolo, and Z. K. Nagy, 2020. “Digital design of an intensified filtration-drying unit for pharmaceutical upstream manufacturing”, 2020 AIChE Annual Meeting (virtual), San Francisco, CA, November 16-20, 2020
- Laky, D., Casas-Orozco, D. M., Mackey, J., Mufti, A., Lee, S., Abdi, M., Feng, X., Wood, E., Laird, C., Reklaitis, G.V., Nagy, Z.K., “Integrated Use of Digital Twin-Based Framework for the Development of a Lomustine Manufacturing Pathway”, Virtual AIChE Annual Meeting, November, 2020.
Education
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